If your PC has a BIOS that handles ISA (and likely PCI too) then if you find a IRQ conflict, it might be due to a shortage of free IRQs. The BIOS often maintains a list of reserved IRQs, reserved for legacy ISA cards. If too many are reserved, the BIOS may not be able to find a free IRQ and will erroneously assign an IRQ to the serial port that creates a conflict. So check to see if all the reserved IRQs are really needed and if not, unreserve an IRQ that the serial port can use. For more details, see Plug-and-Play-HOWTO.